People are great at detecting cold temperatures and also the cool sensation induced by natural substances like menthol, which is common in remedies used to soothe aching muscles. But it hasn’t been entirely clear how we do this.
About a year ago, a group of researchers led by Seok-Yong Lee, Associate Professor of Biochemistry in the Duke University School of Medicine, figured out the architecture of the human and animal cold-sensing protein, an ion channel called TRPM8, which gave them some insight into its function but also raised more questions.
Now, Lee’s team has determined the structure TRPM8 assumes when it is bound to menthol and to another synthetic cooling agent called icilin. The findings, which will appear in Science on Feb. 8, could pave the way toward new treatments for chronic pain and migraine and help patients who suffer from extreme cold sensitivity.
The first U.S. patient to participate in a global study of a stem cell therapy injected directly into the brain to treat stroke disability was enrolled in the clinical trial this week at The University of Texas Health Science Center at Houston (UTHealth).
“At McGovern Medical School at UTHealth, we have been studying cellular therapies as a novel treatment for stroke over the past 10 years. We are very excited to partner with ReNeuron and enroll the first patient into the PISCES III study,” said Sean I. Savitz, MD, the study’s global principal investigator and professor and director of the Institute for Stroke and Cerebrovascular Disease at UTHealth. “This study represents an important next step in the development of novel cellular therapies for chronic stroke and, to date, is the most advanced clinical trial to determine whether neural stem cells improve recovery in patients chronically disabled by stroke.”
Much like an APTA white paper on opioids and pain management published in the summer of 2018, a draft report from the US Department of Health and Human Services (HHS) says that it’s time to address the gaps in the health care system that make it difficult to follow best practices in addressing pain—including improved access to and payment for physical therapy. APTA provided comments to the HHS task force that created the report.
The draft “Report on Pain Management Best Practices” now available for public comment aims to identify “gaps, inconsistencies, updates, and recommendations for acute and chronic pain management best practices” across 5 major interdisciplinary treatment modalities: medication, restorative therapies including physical therapy, interventional procedures, behavioral health approaches, and complementary and integrative health. The entire report is predicated on a set of “key concepts” that emphasize an individualized biopsychosocial model of care that employs a multidisciplinary approach and stresses the need for innovation and research.
Millions of people live with high blood pressure, which can place them at risk of developing cardiovascular diseases. For this condition, doctors typically prescribe blood-lowering drugs, but could exercise help just as well?
According to the Centers for Disease Control and Prevention (CDC), approximately 75 millionadults in the United States have to manage high blood pressure, where it exceeds the threshold of 140 millimeters of mercury (mm Hg).
The condition can increase their risk of developing heart disease or experiencing a stroke, both of which are leading causes of death in the U.S.
THE THING ABOUT building muscle, cutting fat and otherwise getting in shape is, well, you have to work out. No fair, right? But what if someone – or something – else could do a lot of the work for you? Such is the commonly perceived promise of electrical muscle stimulation training, aka EMS, a type of technology that activates your muscles from the outside while you activate them from the inside.
“It’s an efficient workout,” says Jackie Wilson, a lawyer-turned-personal trainer who founded NOVA Fitness Innovation, a network of boutique fitness studios in New York City that offers one-on-one EMS training sessions.
While the specifics vary depending on the model of equipment itself and the type of supervision you’re under, in Wilson’s studios, the training involves wearing a wetsuit-like outfit embedded with 20 electrodes that sit atop major muscle groups like the pecs, biceps and quads. As clients go through a body weight or lightly weighted workout – say, a circuit including squats, pushups and jumping jacks – he or another trained staff member uses a wireless device to send impulses of varying intensities to those muscles that are contracting.
Patients who underwent physical therapy soon after being diagnosed with pain in the shoulder, neck, low back or knee were approximately 7 to 16 percent less likely to use opioids in the subsequent months, according to a new study by researchers at the Stanford University School of Medicine and the Duke University School of Medicine.
For patients with shoulder, back or knee pain who did use opioids, early physical therapy was associated with a 5 to 10 percent reduction in how much of the drug they used, the study found.
Amid national concern about the overuse of opioids and encouragement from the Centers for Disease Control and Prevention and other groups to deploy alternatives when possible, the findings provide evidence that physical therapy can be a useful, nonpharmacologic approach for managing severe musculoskeletal pain.
Pelvic floor muscle therapy (PFMT) “could be included in first‐line conservative management programs” for women with urinary incontinence (UI), according to the authors of a recently updated Cochrane systematic review. While the conclusion itself isn’t new, the revision includes more evidence that makes the case for PFMT even stronger.
Authors analyzed data from 31 trials including a total of 1,817 women. The studies examined whether women were “cured” or “cured or improved” as a result of treatment for stress urinary incontinence (SUI), urgency urinary incontinence (UUI), or mixed urinary incontinence (MUI). Researchers also looked at the effects of PFMT on quality of life.
The results were clear, according to authors: women with all types of UI experienced greater benefit from PFMT than from no treatment or control interventions, which included sham electrical stimulation, placebo drug, or other inactive treatments such as educational pamphlets.
It’s no secret that when it comes to their potential for bacterial awfulness, the children’s ball pits often found in fast food restaurants are the stuff of a germaphobe’s nightmares. Now it turns out that if not properly maintained, ball pits in physical therapy clinics are capable of inducing shudders too.
In a study recently published in the American Journal of Infection Control, researchers tested 6 ball pits in inpatient and outpatient physical therapy clinics in Georgia to find out what, if anything, those pits were harboring at a microbial level. Authors hope that the study will help to spark a conversation about standards for cleaning the enclosures—standards that they say have remained “elusive” to date.
To conduct the analysis, researchers collected 9 to 15 balls taken from different depths in each ball pit, and then swabbed the entire surface of each ball. Samples were then inoculated on agar plates and allowed to grow for 24 hours at 91.4 degrees Fahrenheit. After the incubation, samples were tested for the number of colony-forming units (CFUS) present. Here’s what researchers found:
As the US population continues to age, physical therapists (PTs) and physical therapist assistants (PTAs) will take on an even more transformative role in the health of society. Are you ready?
The 2019 APTA Combined Sections Meeting, set for January 23-26 in downtown Washington, DC, can help keep you on top of some of the latest issues in healthy aging. Check out these suggestions, and find other relevant programming by searching the CSM programming page.
Geriatric Low Back Pain: Managing Influences, Experiences, and Consequences
This session focuses on the biological, psychological, cognitive, and social influences of geriatric low back pain (LBP), and presents a comprehensive model of geriatric LBP that accounts for the interface between pain and impaired movement, as well mobility and health risks associated with geriatric LBP. Find out about age-appropriate measurement tools and interventions for geriatric LBP and learn how to implement a comprehensive, standardized management approach that optimizes recovery and mitigates health risks associated with geriatric LBP. Friday, January 25, 8:00 am–10:00 am.
Not all broken bones heal. But one scientist at the University of Arizona hopes to remedy that problem using a combination of 3D printing and adult stem cells.
“Imagine an impact that causes half of a long bone to shatter so that it can’t be put back together – no current surgical treatment can ensure that kind of injury will heal,” explained John A. Szivek, PhD, a scientist at the UA College of Medicine – Tucson. “This is a really big problem for the military, where explosions or combat injuries can cause big bone defects.”
To help military personnel with these devastating injuries, Dr. Szivek, a biomedical engineer and professor of orthopedic surgery, has received a five-year, $2 million grant from the U.S. Department of Defense to launch a study to determine how to heal bone fractures using a combination of 3D printing and adult stem cells.