A combination of powerful tools has helped scientists identify two new genes that could contribute to osteoporosis through their effect on bone density. The finding could lead to better treatments for the bone-weakening disease.
The study, by researchers at the Children’s Hospital of Philadelphia (CHOP) in Pennsylvania, highlights the importance of understanding the 3D geography of the genome in locating genes that cause disease.
The team points out that identifying DNA variants, or differences, behind diseases, is not necessarily enough to locate the genes that cause the disease. The variants, for example, could be triggers of genes in other parts of the genome.