Common antidepressants interact with opioid med to lessen pain relief

Common antidepressants interact with the opioid pain medication tramadol to make it less effective for pain relief, according to a study from University Hospitals (UH). These findings have important implications for the opioid epidemic, suggesting that some patients suspected of drug-seeking may, in fact, be under-medicated and just are seeking more effective pain relief. They also could help explain why some people exceed the prescribed dose of tramadol, increasing their risk of addiction.

The study was published in the journal Pharmacotherapy.

Researchers reviewed the medication records of 152 patients at UH Cleveland Medical Center and UH Geauga Medical Center who received scheduled tramadol for at least 24 hours. All participants in the study were admitted as inpatients or observation status. Those patients who also were taking the antidepressants Prozac (fluoxetine), Paxil (paroxetine) or Wellbutrin (bupropion) required three times more pain medication per day to control “breakthrough” pain throughout the day, when compared with patients not taking those antidepressants.

Full story at NeuroScience News

New at PT Now: THA Summary, Pain Resources, Clinical Case Studies, More

From nonopioid pain treatment approaches to finding the most effective way to integrate into bundled payment systems, physical therapists (PTs) and physical therapist assistants (PTAs) have a lot to juggle. The latest additions to APTA’s PTNow website make that juggling just a little easier.

The association’s flagship site for evidence-based practice resources continues to expand in ways that help PTs and PTAs easily find the information they need. If you haven’t visited the site lately, check it out soon. New resources include:

Total hip arthroplasty (THA) clinical summary with “quick take” feature
A timely addition now that Medicare’s Comprehensive Care for Joint Replacement bundled payment model is up and running in metropolitan areas across the country, the summary provides information on PT management of patients undergoing THA, including tests and measures, functional outcomes, and gait training measures, associated conditions such as deep venous thrombosis and infection, and more. A quick take feature allows users to easily access just those sections they need at the moment, and additional links on the page connect the summary with other APTA resources, including consumer-focused materials available at MoveForwardPT.com.

Full story of THA summary and pain resources at APTA