Ultra-sturdy bones, with a surprising origin, suggest new osteoporosis approach

A handful of brain cells deep in the brain may play a surprising role in controlling women’s bone density, according to new research by UC San Francisco and UCLA scientists.

In a study published January 11, 2019 inĀ Nature Communications, researchers showed that blocking a particular set of signals from these cells causes female (but not male) mice to build extraordinarily strong bones and maintain them into old age, raising hopes for new approaches to preventing or treating osteoporosis in older women.

“Our collaborators who study bone for a living said they’d never seen bone this strong,” said study senior author Holly Ingraham, Ph.D. “Our current understanding of how the body controls bone growth can’t explain this, which suggests we may have uncovered a completely new pathway that could be used to improve bone strength in older women and others with fragile bones.”

Full story at Medical Xpress